Regional Opportunity Initiatives (ROI) curates grant opportunities that support nonprofits, local governments, schools, and community organizations across the Indiana Uplands region. This page highlights funding aligned with regional priorities. Browse current opportunities below and follow the links provided to learn more about eligibility and application requirements.

Note: Unless otherwise indicated, ROI does not administer these grants.

Applications are due Nov 9 for the Spring 2027 Cohort of ROI’s Grant Writing Fellowship!

Arts & Culture

Community Grants Supporting Arts, Education, Health, and Environment

Max and Victoria Dreyfus Foundation

Funding: $1,000 – $20,000

Deadline: November 10, 2026

Community Development

Spark Good Local Grants

Walmart

Funding: $250 – $5,000

Deadline: Cycle 3 – November 30, 2026

Community Grants Supporting Arts, Education, Health, and Environment

Max and Victoria Dreyfus Foundation

Funding: $1,000 – $20,000

Deadline: November 10, 2026

Supports a wide range of areas including museums, cultural and performing arts, schools, hospitals, educational and skills training, programs for youth, seniors, and people with disabilities, and environmental and wildlife protection.

Grants for Art Scholarship, Conservation, and Exhibitions

The Wyeth Foundation for American Art

Funding: $5,000 – $25,000

Deadline: December 15, 2026

Supports innovative exhibitions exploring new research, museum catalogs and publications, and the conservation and restoration of American masterpieces.

Developing Public Humanities Exhibitions, Historic Sites, and Lectures

National Endowment for the Humanities

Funding: Up to $2,000,000

Deadline: December 16, 2026

Supports exhibitions, historic site interpretations, public lectures, and discussion programs that bring humanities ideas to broad public audiences. Priority topics for 2027 include the 250th anniversary of the American Revolution, civic education, civil discourse, cultural literacy, and the study of Western civilization and influential works of literature and philosophy. Eligible applicants include nonprofits, colleges and universities, Tribal governments, and state and local governments.

Rural Placemaking Studio

Indiana University Center for Rural Engagement & IU ServeDesign Center

Funding: Technical assistance, planning, and design support (no direct project funding)

Supports rural Indiana communities in developing concepts for public spaces, public art, wayfinding, visual communications, and placemaking projects. Selected communities collaborate with Indiana University faculty, staff, and students through a community-centered planning and design process to create more welcoming, useful, and meaningful public spaces.

Spark Good Local Grants

Walmart

Funding: $250 – $5,000

Applications are accepted and reviewed through three application cycles in FY27:

  • Cycle 1: Feb. 1 – April 15
  • Cycle 2: May 1– July 15
  • Cycle 3: Aug. 1 – Nov. 30

Supports local organizations that meet the needs of communities where Walmart operates.

Angel Philanthropy

The Smart Family Fund

Funding: $25,000 – $100,000

Supports and mentors emerging nonprofit organizations and their leaders throughout the U.S. Funding targets early-stage nonprofits with significant impact potential that have not yet demonstrated the efficacy needed to attract large-scale funding. Previous areas of support include social services, arts and culture, economic opportunity, parks and recreation, and education.

Wish Local Empowerment Program

Funding: $500 – $2,000

Supports Black-owned brick-and-mortar retail businesses across the US in covering operating expenses such as workforce retention, rent, inventory, customer research, and community engagement.

Jeffris Heartland Fund

Jeffris Heartland Fund

Supports preservation projects in small towns and cities in the Midwest by covering 50% of the costs of a Historic Structure Report.

CreatINg Places Grant

Indiana Housing & Community Development Authority

Funding: $5,000 – $50,000 with 1:1 fundraising match requirement

Supports projects that activate underutilized public spaces or create new public spaces.

Community Facilities Direct Loan & Grant Program

U.S. Department of Agriculture Office of Rural Development

This program provides affordable funding to development essential community facilities in rural areas.

Community Heart & Soul Seed Grant Program

Funding: Up to $10,000 with a 1:1 cash match requirement

Provides start-up funding for resident-driven groups in small cities and towns looking to implement the Community Heart & Soul model.

Water & Waste Disposal Loan & Grant Program

U.S. Department of Agriculture Office of Rural Development

This program provides funding for clean and reliable drinking water systems, sanitary sewage disposal, sanitary solid waste disposal, and storm water drainage to households and businesses in rural areas.

Laura Bush 21st Century Librarian Program

Institute of Museum and Library Services

Funding: $25,000 – $1,000,000

Deadline: November 13, 2026

Supports projects the build a library and archival workforce capable of meeting the information needs of communities across the country.

Innovation in Two-Year College STEM Education

U.S. National Science Foundation

Funding: Up to $500,000

Deadline: December 9, 2026

Funding is available through two tracks: one focused on improving academic experiences for two-year college students, and one focused on leveraging institutional strengths and innovation.

Agricultural Leadership Grant

CHS Foundation

Funding: $1,000 – $1,430,000

Supports programs that strengthen rural communities and prepare the next generation of agricultural education, leadership training, and career development for students from high school through early professional stages.

Seed Grants for Early Childhood Education Programs

Frances R. Dewing Foundation

Funding: $2,500 – $25,000

Deadlines: April 1, 2026 and October 1, 2026

Provides seed grant funding for new or experimental projects, including creative daycare initiatives, that have the potential to create broader community or educational impact.

Principal Student Support Services Grant

School-Based Healthcare Solutions Network

Provides a fully funded mental health professional for each school campus who will deliver evidence-based mental health support services directly to students.

Children’s Book Project Program Grants

Funding: Up to $1,200 with a 2:1 match requirement

Deadlines: Every April 1 and October 1

Supports rural libraries to purchase new, quality, hardcover children’s books.

Employer Training Grant

Indiana Department of Workforce Development

Offers employers $5,000 per employee (up to $50,000) who is trained, hired, and retained for at least six months in select priority sectors.

Workforce Ready Grant

Indiana Department of Workforce Development

Program for individuals that covers the tuition and fees of qualifying certificate programs across Indiana.

Path to Pro Education Grants

Home Deport Foundation

Funding: In-kind support up to $10,000

Support is provided in the form of Home Depot gift cards that may be used to purchase tools, equipment, building materials, and supplies, or to support new or renovated training spaces for organizations offering vocational training in the construction industry.

Grants for Education, Health, Culture, and Social Services

Hearst Foundations

Funding: Grants over $100,000

Supports nonprofits working across four areas: education including higher education, STEM programs, and college access; health including access to care for low-income populations, behavioral health, and medical research; social services including affordable housing, job training, and youth development; and culture including arts education, artist development, and science education. 

Community Impact Fund

Bristol Myers Squibb

Funding: $5,000-$50,000

Deadline: December 15, 2026

Supports nonprofit organizations working to improve access to care for medically underserved populations. Funding priorities include oncology, hematology, immunology, neuroscience, and cardiovascular disease, with an emphasis on patient navigation, early detection, caregiver support, and addressing barriers to health equity. Organizations must be nominated to be considered for funding.

Labcorp Charitable Foundation Grants

Funding: $5,000 – $25,000

Supports community-based non-profit organizations advancing health, education, and well-being.

Mothers in Medicine Fund

Zorya Foundation

Funding: Up to $12,000

Provides childcare support to women working in healthcare who are mothers or primary caregivers.

Grants for Hunger Relief and Sustainability

The Kroger Co.

Deadline: December 4, 2026

Supports hunger relief, sustainability, health and nutrition, disaster relief, diversity and inclusion, and education and youth development.

Regional Opportunity Initiatives periodically offers grant opportunities that support regional collaboration, education and workforce initiatives, and community development across the Indiana Uplands. Please check back soon or subscribe to our newsletter for updates.

ROI is committed to supporting organizations in the Indiana Uplands region.

If you need assistance identifying funding opportunities or determining whether a grant is a good fit for your project, please email us at info@regionalopportunityinc.org.

New funding opportunities are added regularly. Sign up for the ROI newsletter to receive updates on grants, funding announcements, and regional initiatives.